Generic Name: hydrocodone and phenylephrine (high droe KOE dohn and fen ill EH frin)
Brand names: Lortuss HC, Nalex-DH, Tusdec-HC, Phenylephrine HD
What is hydrocodone and phenylephrine?
Hydrocodone is a narcotic. It is a pain reliever and a cough suppressant.
Phenylephrine is a decongestant. It works by constricting (shrinking) blood vessels (veins and arteries) in the body. Constriction of blood vessels in the sinuses and nose decreases congestion.
Hydrocodone and phenylephrine is used to treat cough and nasal congestion associated with the common cold, sinus infections, the flu, and bronchitis.
Hydrocodone and phenylephrine may also be used for purposes other than those listed in this medication guide.
What is the most important information I should know about hydrocodone and phenylephrine?
Use caution when driving, operating machinery, or performing other hazardous activities. Hydrocodone and phenylephrine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking hydrocodone and phenylephrine.
Hydrocodone and phenylephrine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any other medicine without first talking to your doctor.
Hydrocodone is habit forming. It is possible become physically and/or psychologically dependent on the medication. Do not take more than the prescribed amount of medication or take it for longer than is directed by your doctor. Withdrawal effects may occur if hydrocodone and phenylephrine is stopped suddenly after several weeks of continuous use. Your doctor may recommend a gradual reduction in dose.
What should I discuss with my healthcare provider before taking hydrocodone and phenylephrine?
Do not take hydrocodone and phenylephrine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), or selegiline (Eldepryl) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.
Before taking hydrocodone and phenylephrine, tell your doctor if you have
epilepsy or another seizure disorder;
been diagnosed with sleep apnea (periods of not breathing during sleep);
thyroid problems;
asthma;
a head injury;
Addison's disease;
diabetes;
glaucoma;
bladder problems or difficulty urinating;
- an enlarged prostate;
high blood pressure, irregular heartbeats, or any type of heart disease;
- kidney problems; or
- liver problems.
You may not be able to take hydrocodone and phenylephrine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.
Hydrocodone and phenylephrine is in the FDA pregnancy category C. This means that it is not known whether hydrocodone and phenylephrine will be harmful to an unborn baby. Do not take hydrocodone and phenylephrine without first talking to your doctor if you are pregnant or could become pregnant during treatment. Hydrocodone and phenylephrine passes into breast milk and may be harmful to a nursing baby. Do not take hydrocodone and phenylephrine without first talking to your doctor if you are breast-feeding a baby. If you are over 65 years of age, you may be more likely to experience side effects from hydrocodone and phenylephrine. Your doctor may prescribe a lower dose of this medication.
How should I take hydrocodone and phenylephrine?
Take hydrocodone and phenylephrine exactly as directed by your doctor. If you do not understand the directions on your prescription bottle, ask your pharmacist, nurse, or doctor to explain the instructions to you.
Hydrocodone and phenylephrine can be taken with or without food.
Take the oral tablets and capsules with a full glass of water.
To ensure that you get a correct dose, measure the liquid form of hydrocodone and phenylephrine with a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.
Do not take more of this medication or take it for longer than is recommended. If your symptoms do not improve, or if they worsen, talk to your doctor. Hydrocodone is habit forming. It is possible become physically and/or psychologically dependent on the medication. Do not take more than the prescribed amount of medication or take it for longer than is directed by your doctor. Withdrawal effects may occur if hydrocodone and phenylephrine is stopped suddenly after several weeks of continuous use. Your doctor may recommend a gradual reduction in dose. Store hydrocodone and phenylephrine at room temperature away from moisture and heat.
See also: Hydrocodone and phenylephrine dosage (in more detail)
What happens if I miss a dose?
Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.
What happens if I overdose?
Seek emergency medical attention if an overdose is suspected.
Symptoms of a hydrocodone and phenylephrine overdose may include extreme drowsiness, dizziness, headache, seizures, dry mouth, cold and clammy skin, flushing, nausea, vomiting, difficult or decreased breathing, and unconsciousness.
What should I avoid while taking hydrocodone and phenylephrine?
Use caution when driving, operating machinery, or performing other hazardous activities. Hydrocodone and phenylephrine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking hydrocodone and phenylephrine.
Hydrocodone and phenylephrine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any other medicine without first talking to your doctor.
Do not take other over-the-counter cough, cold, allergy, diet, pain, or sleep medications while taking hydrocodone and phenylephrine without first talking to your pharmacist or doctor. Other medications may also contain hydrocodone, phenylephrine, or other similar drugs, and you may accidentally take too much of these medicines.
Hydrocodone and phenylephrine side effects
If you experience any of the following serious side effects, stop taking hydrocodone and phenylephrine and seek emergency medical attention or contact your doctor immediately:
a rare but serious allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); or
confusion, hallucinations, or unusual behavior.
Other, less serious side effects may be more likely to occur. Continue to take hydrocodone and phenylephrine and talk to your doctor if you experience
dizziness, drowsiness, or sleepiness;
restlessness or irritability;
blurred vision;
constipation;
dry mouth;
nausea, vomiting, or decreased appetite;
muscle twitches;
sweating;
itching; or
decreased urination.
Hydrocodone is habit forming. It is possible become physically and/or psychologically dependent on the medication. Do not take more than the prescribed amount of medication or take it for longer than is directed by your doctor. Withdrawal effects may occur if hydrocodone and phenylephrine is stopped suddenly after several weeks of continuous use. Your doctor may recommend a gradual reduction in dose.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Hydrocodone and phenylephrine Dosing Information
Usual Adult Dose for Cough and Nasal Congestion:
hydrocodone-phenylephrine 3.75 mg-7.5 mg/5 mL oral liquid:
5 mL orally every 4 hours not to exceed 30 mL/24 hours.
hydrocodone-phenylephrine 2.5 mg-5 mg/5 mL oral liquid:
5 to 10 mL orally every 4 to 6 hours not to exceed 60 mL/24 hours.
Usual Pediatric Dose for Cough and Nasal Congestion:
6 years to 11 years:
hydrocodone-phenylephrine 3.75 mg-7.5 mg/5 mL oral liquid:
2.5 mL orally every 4 hours not to exceed 15 mL/24 hours.
hydrocodone-phenylephrine 2.5 mg-5 mg/5 mL oral liquid:
5 mL orally every 4 to 6 hours not to exceed 30 mL/24 hours.
12 years or older:
hydrocodone-phenylephrine 3.75 mg-7.5 mg/5 mL oral liquid:
5 mL orally every 4 hours not to exceed 30 mL/24 hours.
hydrocodone-phenylephrine 2.5 mg-5 mg/5 mL oral liquid:
5 to 10 mL orally every 4 to 6 hours not to exceed 60 mL/24 hours.
What other drugs will affect hydrocodone and phenylephrine?
Do not take hydrocodone and phenylephrine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), or selegiline (Eldepryl) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.
Hydrocodone and phenylephrine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any medicine unless your doctor approves.
Do not take other over-the-counter cough, cold, allergy, diet, pain, or sleep medications while taking hydrocodone and phenylephrine without first talking to your pharmacist or doctor. Other medications may also contain hydrocodone, phenylephrine, or other similar drugs, and you may accidentally take too much of these medicines.
Drugs other than those listed here may also interact with hydrocodone and phenylephrine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.
More hydrocodone and phenylephrine resources
- Hydrocodone and phenylephrine Side Effects (in more detail)
- Hydrocodone and phenylephrine Dosage
- Hydrocodone and phenylephrine Use in Pregnancy & Breastfeeding
- Hydrocodone and phenylephrine Drug Interactions
- Hydrocodone and phenylephrine Support Group
- 0 Reviews for Hydrocodone and phenylephrine - Add your own review/rating
Compare hydrocodone and phenylephrine with other medications
- Cough and Nasal Congestion
Where can I get more information?
- Your pharmacist has more information about hydrocodone and phenylephrine written for health professionals that you may read.
See also: hydrocodone and phenylephrine side effects (in more detail)
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